Ruming Chen PhD, Cambridge 2004
Education   E
1999.10-2004.5		Postgraduate Student in Biological Science PhD thesis：Proteomic Study of Mitochondrial Proteins Supervisor：Professor Sir John E. Walker, FRS, FMedSci Department：School of Biological Science, Cambridge University Laboratory：Medical Research Council Mitochondrial Biology Unit College Membership：St Edmund’s College
1989.8-1993.6		Undergraduate Student in Food Science Thesis：Preparation of  Peptides from Soybean Proteolysis Supervisor：Professor Pingfan Rao Department：Department of Biological Science and Engineering, Fuzhou University
Employment
2015.4-present		Founder Chairman, CEO, CTO Greenase Biosynthesis Ltd. (Xiamen, China) Gene engineering,  Heterologous Expression of Recombinant Proteins, Biosynthesis of Organic Molecules.
2010.5-2015.10		Research Associate Cambridge Institute of Medical Research (CIMR)/Institute of Metabolic Science, Cambridge University Crystal Structures of Key Proteins involved in Cellular Protein Synthesis With Professor David Ron, FRS, FMedSci
2011.7-Present		Adjunct Professor School of Life Science, Harbin Institute of Technology Structural and Functional Studies of Membrane Protein Complexes in Mitochondria and Endoplasmic Reticulum
2007.3-2010.5		Investigative Scientist Proteomic Studies of Mitochondrial ATP Synthase and Complex I With Professor Sir John E. Walker, FRS, FMedSci Medical Research Council Mitochondrial Biology Unit (MRC-MBU)
2004.6-2007.2		Career Development Fellow Mass Spectrometric Analysis of Mitochondrial Membrane Proteins and their Post-translational Modification With Professor Sir John E. Walker, FRS, FMedSci Medical Research Council Mitochondrial Biology Unit (MRC-MBU)
1993.9-1999.9		Research Assistant Purifcation, Analysis and Characterization of Proteins With Professor Pingfan Rao Institute of Biotechnology, Fuzhou University
Publications
		1. Chen R, Rato C, Yan Y, Crespillo-Casado A, Clarke HJ, Harding HP, Marciniak SJ, Read RJ, Ron D. (2014) G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife/eLife.04871. 2. Chen R, Yan Y, Preissler S, Rato C, Ding S, Fearnley IM, Read RJ, Ron D. (2015, draft) Crystal Structure of AMPylated BiP at 1.86 Å. 3. Preissler S, Rato C, Chen R, Antrobus R, Ding S, Fearnley IM, Ron D. (2015, submitted) AMPylation matches BiP activity to client protein load to prevent over‐chaperoning of the endoplasmic reticulum. Elife. 4. Chen R, Runswick MJ, Carroll J, Fearnley IM, Walker JE. (2007) Association of two proteolipids of unknown function with ATP synthase from bovine heart mitochondria. FEBS Lett. 581(17):3145-8. 5. Chen R, Fearnley IM, Peak-Chew SY, Walker JE. (2004) The phosphorylation of subunits of complex I from bovine heart mitochondria. J Biol Chem. 279:26036-45 6. Chen R, Fearnley IM, Palmer DN, Walker JE. (2004) Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease. J Biol Chem. 279(21):21883-7 7. Chen R. (Patent) Biosynthesis of Bioactive Peptides by Gene engineering.
Awards
2004-2007		Medical Research Council Career Development Fellowship
1999-2003		Overseas Research Studentship (ORS), the Secretary of State for Education and Science Cambridge Trust Scholarship